Learn the Latest for High-Risk Breast Cancer Patients Register Today

Information for clinicians

What's the chemotherapy effectiveness in premenopausal women?

Premenopausal women with early-stage ER positive/HER2 negative breast cancer can sometimes be overtreated with chemotherapy.1,2 At what point do the risks of chemotherapy and its side-effects outweigh the benefits for young women?

EndoPredict can answer this with its prediction of individual chemotherapy benefit, allowing you to determine at 10 years if the risk of chemotherapy is greater than the chemotherapy benefit for your individual patient. Premenopausal EPclin low-risk patients have on average a 3% risk of distant recurrence and an expected chemotherapy benefit of below 3%. Therefore, the 2-3% risk of more serious side-effects by chemotherapy outweighs the expected benefit from chemotherapy.

Every woman, regardless of her age or menopausal status, can know if she would benefit from chemotherapy or not.

EndoPredict guides confident breast cancer treatment decisions with the future in mind

EndoPredict is the only second generation breast cancer recurrence test validated for premenopausal and postmenopausal women with early-stage breast cancer that is ER positive, HER2 negative, node negative or positive3-9 – and the only second generation test with level of evidence 1A data.10,11

New data provide EndoPredict with prospective proof of previous published validation studies to make a confident breast cancer prognosis and treatment decision for premenopausal women. This study shows that EndoPredict clearly identifies young women who might forego chemotherapy.12

EndoPredict is also the only test providing a 15-year recurrence risk for long-term breast cancer prognosis3 – learn more about EndoPredict and long-term recurrence risk.

How does EndoPredict perform compared to Oncotype DX® in premenopausal patients with node positive and node negative disease?

For the first generation Oncotype DX® test, two prospective randomized controlled trials are unclear about predicting chemotherapy benefit for node negative and node positive patients in a premenopausal setting, potentially leading to overtreatment in younger women.13,14

EndoPredict is the only second generation gene expression test validated in premenopausal women

EndoPredict identifies low-risk premenopausal patients, regardless of nodal status

Similar 10-year DRFS with or without ovarian function suppression

Four year prospective outcome data of premenopausal women12

Level of evidence 1A data confirm EndoPredict identifies low-risk patients with node positive disease10

This is the first prospective validation data in a randomized controlled trial of a second generation test, and confirms previous prospective-retrospective validation data

EndoPredict identifies low-risk premenopausal women with node positive disease7

References

  1. Cancello, Giuseppe, and Montagna, Emilia. “Treatment of breast cancer in young women: do we need more aggressive therapies?”. Journal of Thoracic Disease, vol. 5, Suppl 1, 2013, pp. S47-54
  2. Subhedar, Preeti D, and Sarah A McLaughlin. “Breast Cancer In The Young Patient: Review Of Therapy And Treatment Considerations“. Breast Cancer Management, vol 9, no. 2, Reviews 2020
  3. Filipits, Martin et al. “A New Molecular Predictor Of Distant Recurrence In ER-Positive, HER2-Negative Breast Cancer Adds Independent Information To Conventional Clinical Risk Factors“. Clinical Cancer Research, vol 17, no. 18, 2011, pp. 6012-6020
  4. Filipits, Martin et al. “Prediction Of Distant Recurrence Using Endopredict Among Women With ER+, HER2− Node-Positive And Node-Negative Breast Cancer Treated With Endocrine Therapy Only“. Clinical Cancer Research, vol 25, no. 13, 2019, pp. 3865-3872
  5. Buus, Richard et al. “Comparison Of Endopredict And Epclin With Oncotype DX Recurrence Score For Prediction Of Risk Of Distant Recurrence After Endocrine Therapy“. Journal Of The National Cancer Institute, vol 108, no. 11, 2016, p. djw149
  6. Sestak, Ivana et al. “Prediction Of Chemotherapy Benefit By Endopredict In Patients With Breast Cancer Who Received Adjuvant Endocrine Therapy Plus Chemotherapy Or Endocrine Therapy Alone“. Breast Cancer Research And Treatment, vol 176, no. 2, 2019, pp. 377-386
  7. Martin, Miguel et al. “Clinical Validation Of The Endopredict Test In Node-Positive, Chemotherapy-Treated ER+/HER2− Breast Cancer Patients: Results From The GEICAM 9906 Trial“. Breast Cancer Research, vol 16, no. 2, 2014, p. R38
  8. Dubsky, Peter et al. “The Endopredict Score Provides Prognostic Information On Late Distant Metastases In ER+/HER2− Breast Cancer Patients“. British Journal Of Cancer, vol 109, no. 12, 2013, pp. 2959-2964
  9. Constantinidou, Anastasia et al. “Clinical Validation Of Endopredict In Premenopausal Women With Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Primary Breast Cancer.“. Journal Of Clinical Oncology, vol 39, no. 15_suppl, 2021, pp. 537-537
  10. Penault-Llorca, Frederique et al. “Prognostic value of EndoPredict test in patients screened for UNIRAD, a UCBG randomized, double blind, phase III international trial evaluating the addition of *** (EVE) to adjuvant hormone therapy (HT) in women with high risk HR+, HER2- early breast cancer (eBC)“. SABCS 2021, PD-09-08 Spotlight Poster Discussion 9
  11. Simon, Richard et al. “Use Of Archived Specimens In Evaluation Of Prognostic And Predictive Biomarkers”. Journal Of The National Cancer Institute, vol 101, no. 21, 2009, pp. 1446-1452
  12. Vázquez-Juarez, Daniela et al. ”Follow-up of prospective cohort of Mexican premenopausal women with breast cancer who received guided adjuvant treatment with the EndoPredict assay.” SABCS 2021, P4-05-15
  13. Sparano, Joseph A. et al. “Adjuvant Chemotherapy Guided By A 21-Gene Expression Assay In Breast Cancer“. New England Journal Of Medicine, vol 379, no. 2, 2018, pp. 111-121
  14. Kalinsky, Kevin et al. “21-Gene Assay To Inform Chemotherapy Benefit In Node-Positive Breast Cancer“. New England Journal Of Medicine, vol 385, no. 25, 2021, pp. 2336-2347